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IRS2 integrates insulin/IGF1 signalling with metabolism, neurodegeneration and longevity

[DOI] [PMC free article] [PubMed] 23.Morgante G, Darino I, Span A, Luisi S, Luddi A, Piomboni P, Governini L, De Leo

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These components can be divided into proximal components, including insulin receptors, insulin receptor substrates, PI3K, and AKT/PKB, and distal components, representing various components downstream of AKT/PKB, including TBC1D4, GSK3, and PDE3B